![]() Shi Z, Jiang Y, Weir-McCall J, Wang X, Teng Z (2022), “COVID-19 and Atherosclerosis: looking beyond the acute crisis” Emergency and Critical Care Medicine Shi Y, Zheng J, Yang N, Chen Y, Sun J, Zhang Y, Zhou X, Gao Y, Li S, Zhu H, Acosta-Cabronero J, Xia P, Teng Z (2022), “The effect of subbranch for the quantification of local hemodynamic environment in the coronary artery: a CTA-based computational fluid dynamic analysis” Emergency and Critical Care Medicine ![]() Qin B, Chen S, Miao P, Teng Z (2022), “Cerebral Vessel Extraction: From Image Acquisition to Machine Learning” Frontiers in Neuroscience 16:972389 Li Z, Luo T, Wang S, Jia H, Gong Q, Liu X, Sutcliffe MPF, Zhu H, Liu Q, Chen D, Xiong J, Teng Z (2022), “Mechanical and Histological Characteristics of Aortic Dissection Tissues ” Acta Biomaterialia S1742-7061(22)00179-9 Huang Y, Wang S, Luo T, Du H, Sun C, Sadat U, Schonlieb C, Gillard JH, Zhang J, Teng Z (2022), “Estimation of the zero-pressure computational start shape of atherosclerotic plaques: improving the backward displacement method with deformation gradient tensor” Journal of Biomechanics 131: 110910 Xie S, Ran Y, Wang X, Zhang Y, Fu Q, Ren Y, Liu J, Teng Z, Cheng J (2023), “Diagnostic potential of routine brain MRI and high-resolution, multi-contrast vessel wall imaging in the detection of internal carotid artery dissection” Frontiers in Neurology 2022 Tang H, Zhang Z, He Y, Shen J, Zheng J, Gao W, Sadat U, Wang M, Wang Y, Ji X, Chen Y, Teng Z (2023), “Automatic classification and segmentation of atherosclerotic plaques in the intravascular optical coherence tomography (IVOCT)” Biomedical Signal Processing and Control 85: 104888 He J, Yang W, Wu W, Sun X, Li S, Yin G, Zhuang B, Xu J, Zhou D, Zhang Y, Wang Y, Zhu L, Sharma P, Sirajuddin A, Teng Z, Kureshi F, Zhao S, Lu M (2023), “Clinical features, myocardial strain and tissue characteristics of heart failure with preserved ejection fraction in patients with obesity: A prospective cohort study” eClinicalMedicine 55: 1-13 Gu S, Huang Y, Costopoulos C, Jessney B, Bourantas C, Teng Z, Losdat S, Maehara A, Raber L, Stone GW, Bennett MR (2023), “Heterogeneous plaque-lumen geometry is associated with major adverse cardiovascular events” European Heart Journal Open 3: 1-11 We focus on: 1) development of MR sequences 2) mechanical analysis using structure-only, CFD and FSI simulation 3) image processing 4) clinical studies to assess the risk of various compositional features and critical mechanical conditions 5) the pathological impact of stress/stretch concentration at cellular, molecular and genetic levels. Therefore, critical mechanical conditions should be integrated with compositional features for an accurate vulnerability assessment. ![]() The rupture possibly occurs if such loading exceeds its material strength. ![]() Moreover, plaques are subject to mechanical loading due to blood pressure and flow. Evidence has shown the correlation between compositional features and plaque vulnerability. The rupture of atherosclerotic plaques is responsible for most clinical symptoms of heart attack and stroke. Atherosclerotic plaques are multi-component structures composed of a lipid core, calcium or haemorrhage enclosed by a fibrous cap, which can be captured by MRI. ![]()
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